Takeda's psoriasis pill developed with AI assistance succeeds in trials Psoriasis is a chronic autoimmune disorder that causes rashes marked by itchy, scaly rashes and afflicts more than 125 million people worldwide. Takeda Pharmaceutical announced that its oral psoriasis drug zasocitinib proved safe and effective in late-stage trials, marking a milestone in its effort to treat the incurable skin condition and offset looming revenue pressure. Patients with moderate-to-severe plaque psoriasis who took the once-daily pill showed significantly clearer skin compared with those on placebo or the existing therapy apremilast, the company said in a statement Thursday. Takeda plans to submit data to the U.S. Food and Drug Administration and other regulators beginning in fiscal year 2026. If approved, zasocitinib would join the small but growing oral psoriasis treatments -- long a market dominated by ointments and injectable antibody therapies -- and stand out as one of the first drugs discovered with the help of artificial intelligence.

We develop an arbitrage-free deep learning framework for yield curve and bond price forecasting based on the Heath-Jarrow-Morton (HJM) term-structure model and a dynamic Nelson-Siegel parameterization of forward rates. Our approach embeds a no-arbitrage drift restriction into a neural state-space architecture by combining Kalman, extended Kalman, and particle filters with recurrent neural networks (LSTM/CLSTM), and introduces an explicit arbitrage error regularization (AER) term during training. The model is applied to U.S. Treasury and corporate bond data, and its performance is evaluated for both yield-space and price-space predictions at 1-day and 5-day horizons. Empirically, arbitrage regularization leads to its strongest improvements at short maturities, particularly in 5-day-ahead forecasts, increasing market-consistency as measured by bid-ask hit rates and reducing dollar-denominated prediction errors.

AQA dataset structured on curriculum learning principles.

We introduce Breaking Bad, a large-scale dataset of fractured objects.

We develop a task-oriented spoken dialogue system (SDS) that regulates emotional speech based on contextual cues to enable more empathetic news conversations. Despite advancements in emotional text-to-speech (TTS) techniques, task-oriented emotional SDSs remain underexplored due to the compartmentalized nature of SDS and emotional TTS research, as well as the lack of standardized evaluation metrics for social goals. We address these challenges by developing an emotional SDS for news conversations that utilizes a large language model (LLM)-based sentiment analyzer to identify appropriate emotions and PromptTTS to synthesize context-appropriate emotional speech. We also propose subjective evaluation scale for emotional SDSs and judge the emotion regulation performance of the proposed and baseline systems. Experiments showed that our emotional SDS outperformed a baseline system in terms of the emotion regulation and engagement. These results suggest the critical role of speech emotion for more engaging conversations. All our source code is open-sourced at https://github.com/dhatchi711/espnet-emotional-news/tree/emo-sds/egs2/emo_news_sds/sds1

This paper addresses the gap in predicting turn-taking and backchannel actions in human-machine conversations using multi-modal signals (linguistic, acoustic, and visual). To overcome the limitation of existing datasets, we propose an automatic data collection pipeline that allows us to collect and annotate over 210 hours of human conversation videos. From this, we construct a Multi-Modal Face-to-Face (MM-F2F) human conversation dataset, including over 1.5M words and corresponding turn-taking and backchannel annotations from approximately 20M frames. Additionally, we present an end-to-end framework that predicts the probability of turn-taking and backchannel actions from multi-modal signals. The proposed model emphasizes the interrelation between modalities and supports any combination of text, audio, and video inputs, making it adaptable to a variety of realistic scenarios. Our experiments show that our approach achieves state-of-the-art performance on turn-taking and backchannel prediction tasks, achieving a 10% increase in F1-score on turn-taking and a 33% increase on backchannel prediction. Our dataset and code are publicly available online to ease of subsequent research.